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The Berkeley Synchrotron Infrared Structural Biology (BSISB) program focuses on developing and providing breakthrough technologies in deciphering the relationship between genome and functional processes, and identifying the connection between the genome and natural environments. In living cells, dynamic functional processes act together to enable efficient responses to internal and external environmental perturbations. We continue to develop and expand synchrotron infrared (SIR) spectromicroscopy technologies for tracking the chemical composition and reactions of cells responding to internal or external stimuli and perturbations. This includes the integration of mass spectrometry analysis to provide precise molecular characterization of these dynamic systems.
We will also develop visible (VIS) hyperspectral/fluorescence microscopy approaches for simultaneously tracking changes in cellular morphology, structure, and biological processes such as gene expression and signaling during SIR experiments. Living cells are highly sensitive to their immediate environment. We also are developing new detector technologies. The development of live-cell chemical/biological imaging technologies is aided by a new generation of microfluidics platform. Our technological research and development effort is accelerated by collaborations on wide ranging research projects of bioenergy, medical, and environmental studies. Synergistic interactions with additional research groups will provide interdisciplinary expertise and scientific critical mass to meet the challenges of live-cell analysis and characterization.