Molecular Microbial Biology

Molecular Microbial Biology PhotoThe projects within molecular microbial biology research conducted in the Environmental Remediation & Water Resources Program largely focus on characterizing microbial properties and processes as a function of environmental perturbations. Such work seeks to understand the ability of bacteria and other organisms to respond to and survive external stresses, such as those brought about by the introduction of contaminants or remediation treatments. A significant fraction of research in this area is funded by DOE Genomes-to-Life and relies on the use and advance of gene arrays and synchrotron characterization approaches.

 

Related Projects

Genomes to Life (GTL) SFA

DOE Molecular Microbiology Programs: Individual and Collective Projects

  • High Throughput Identification and Structural Characterization of Multiprotein Complexes During Stress Response in Desulfovibrio Vulgaris
    • PI: Hazen
    • Sponsor: DOE Biological Research—Molecular Biology
  • Low Dose High-Resolution Infrared Spectromicroscopy for Molecular Characterization and Imaging of Bystander Effects in Real Time
    • PI: Holman
    • Sponsor: DOE Life Sciences—Structural Biology
  • Synchrotron Infrared (SIR) Spectromicroscopy of Living Microbial Cells
    • PI: Holman
    • Sponsor: DOE Life Sciences—Structural Biology
  • Predicting the Stability/Status and Mobility of Engineered Nanomaterials after Their Release into Soils and Groundwater (see link above  [also listed in Environmental Remediation Research Area])
    • PI: Wan
    • Sponsor: GTL
  • Analysis of Microbial Community Structure and Interactions in Natural Metal-Contaminated Ecosystems
    • PI: Andersen
    • Sponsor: DOE Life Sciences—Structural Biology
  • Dynamic Spatial Organization of Multi-Protein Complexes Controlling Microbial Polar Organization, Chromosome Replication, and Cytokinesis
    • PI: Andersen
    • Sponsor: DOE Biological Research —Molecular Biology
  • Profiling Microbial Identity and Activity: Novel Applications of NanoSIMS and High Density Microarrays
    • PI: Brodie
    • Sponsor: GTL

NIH

  • Data Analysis and Coordination Center for the Human Microbiome Project
    • LBNL PI: Andersen w/U. of Maryland
    • Sponsor: NIH-NIAID [National Institute of Allergy and Infectious Diseases]
  • Discovery of Signature SNPs to Distinguish Yersina pestis Strains by Arrays
    • PI: Andersen
    • Sponsor: NIH-NIAID
  • Quantifying Gene Expression to Predict and Optimize Reductive Dechlorination by Dehalococcides spp.
    • PI: Andersen
    • Sponsor: NIH-NIEHS [National Institute of Environmental Health Sciences]
  • Resequencing Microarray for Detection and Antimicrobial Resistance Profiling
    • PI: Brodie
    • Sponsor: NIH/NIAID

NASA

  • Detection of Biosustainable Energy in the Deep Subsurface of Earth and Mars (also listed in Bioenergy Research Area)
    • LBNL PI: Hazen w/U. of Indiana
    • Sponsor: NASA
  • Cataloging Microbial Diversity
    • LBNL PI: Andersen w/Cal Tech,
    • Sponsor: NASA

Other Projects

  • Application of Microarrays and qPCR
    • LBNL PI: Andersen w/ Alvarez-Cohen
    • Sponsor: DOD-SERDP
  • Direct Rapid Detection Based on Microbial Census—PhyloChip (also listed in Water Resources Research Area)
    • PI: Andersen
    • Sponsor: Marin County
  • Monitoring the Montecito Outflow Wastewater Plume (also listed in Water Resources Research Area)
    • PI: Andersen
    • Sponsor: Heal the Ocean